Table 3. Chromosomal localization and relative cloning frequencies of cDNAs derived from transcribed HERV-E4-1 loci in malignant and non-malignant tissue of patient no. 2.
| Transcript1 | Location of amplicon(proviral locus)2 | Chrom. localization | cloning frequency in non-malignant tissue (%) | cloning frequency in malignant tissue (%) | Proximity to genes (<100 kb distance) | found in tissue,reference |
| HERV-Ec1 | chr1∶185155301–185155383 | 1q31.1 | 29% | 7% | PLA2G4A, withinintron 7 | – |
| HERV-Ec6 (ERVE-4) | chr6∶89432125–89432208 | 6q15 | 36% | 20% | RNGTT, withinintron 14 | thalamus (Genbank; AK125006) |
| HERV-Ec7 | chr7∶97420616–97420698 | 7q21.3 | 14% | 40% | ASNA (5′, 81 kb) OCM2 (3′, 31 kb) | – |
| HERV-Ec8 (ERVE-3) | chr8∶8070254–8070336 or chr8∶12392139–123922213 | 8p23.1 or8p23.1 | 14% | 0% | – | leukemic cells (Prusty et al. [58]) |
| HERV-Ec11 | chr11∶3456532–3456614 | 11p15.4 | 0% | 7% | ZNF195 (5′, 99 kb) | – |
| HERV-Ec13 | chr13∶40349963–40350045 | 13q14.1 | 7% | 26% | SLC25A15 (5′, 68 kb) SUGT1L1 (3′, 34 kb) | – |
| 100% (14)4 | 100% (15)4 |
1
aliases according to HUGO Gene Nomenclature Committee are in parentheses [90].
2
Chromosomal localization of MOP-PCR amplicons according to the hg18/March 2006 human reference genome sequence as given by the UCSC Genome Browser.
3
HERV-Ec8 was mapped within a duplicated genome region, with both HERV-Ec8 sequences displaying only 20 nt differences along 8 kb. Assignment to one or the other locus is therefore not possible due to high sequence similarity.
4
Total number of sequenced cDNA clones.
Abbreviations: no., number; chr, chromosome.