Figure 6. Lymphoma-like T cell infiltration is transplantable into Rag1^−/− mice.

A. Flow cytometric analysis of HMNCs from donor mouse showing a TCRβ⁺NK1.1⁺CD4⁻CD8⁻ phenotype. B. Representative flow cytometric analysis of splenic and hepatic MNCs from recipient mice 6 weeks post-transfer. C, Intracellular IFN-γ and IL-2 production. D. H&E stained spleen and liver sections from Rag1^−/− recipient mice 6 weeks post-transfer of 2×10⁴ or 2×10⁵ HMNCs from inbred dnTGFβRII mice with lymphomatous lesions. E. Total HMNCs in Ly5.1Rag1^−/− recipient mice six weeks post-transfer. Ly5.1Rag1^−/− mice were adoptively transferred with 2×10⁴ or 2×10⁵ hepatic mononuclear cells from inbred dnTGFβRII mice with (n = 4) or without (n = 3) lymphomatous lesions, respectively.