Table 3. Hazard ratios of dementia in patients with and without hypnotic usage stratified by age and sex.

Group	Hypnotic Users, No. (%) (N = 5693)		Hypnotic Nonusers, No. (%) (N = 28,465)		HR	(95% CI)	P Value
All	220/5473	(3.86)	424/28041	(1.49)	2.34	(1.92–2.85)	<.001
Sex
Male	97/2423	(3.85)	183/12417	(1.45)	2.28	(1.68–3.10)	<.001
Female	123/3050	(3.88)	241/15624	(1.52)	2.39	(1.85–3.09)	<.001
Age
50–65	27/2758	(0.97)	22/13903	(0.16)	5.22	(2.62–10.41)	<.001
>65	193/2715	(6.64)	402/14138	(2.76)	2.33	(1.90–2.88)	<.001

Abbreviations: CI, confidence interval; HR, hazard ratio.

All models are analyzed by Cox regression adjusted for hypertension, diabetes, hyperlipidemia, and stroke.