Table 3. Outcomes according to subtype.
Total Number | Cumulative mortality, all-cause | One year mortality, all-cause | LVEF response | |||||||||||
LCM A | Plac. | Buc. | Plac,% | Buc,% | Hazard ratio (95% CI) | p | Plac,% | Buc,% | Odds ratio(95% CI) | p | Plac,% | Buc,% | OR (95% CI) | p |
A1 | 99 | 109 | 44.4 | 43.1 | 0.97 (0.64–1.46) | 0.88 | 19.2 | 17.4 | 0.89 (0.44–1.80) | 0.74 | 15.2 | 13.8 | 0.89 (0.41–1.95) | 0.76 |
A2 | 74 | 87 | 13.5 | 19.5 | 1.45 (0.68–3.20) | 0.35 | 2.7 | 2.3 | 0.85 (0.12–6.20) | 0.87 | 23.0 | 37.9 | 2.05 (1.03–4.17) | 0.04 |
A3 | 103 | 83 | 22.3 | 18.1 | 0.77 (0.40–1.48) | 0.43 | 11.7 | 4.8 | 0.38(0.12–1.24) | 0.11 | 15.5 | 39.8 | 3.59 (1.82–7.31) | 0.0003 |
A4 | 89 | 73 | 23.6 | 24.7 | 0.99 (0.53–1.86) | 0.99 | 15.7 | 12.3 | 0.75 (0.31–1.83) | 0.54 | 15.7 | 27.4 | 2.02 (0.93–4.43) | 0.07 |
A5 | 45 | 42 | 42.2 | 26.2 | 0.61 (0.29–1.28) | 0.18 | 11.1 | 11.9 | 1.08 (0.28–4.04) | 0.91 | 8.9 | 28.6 | 4.10 (1.29–15.82) | 0.02 |
A6 | 153 | 164 | 24.2 | 14.0 | 0.52 (0.31–0.88) | 0.01 | 7.2 | 3.7 | 0.49 (0.18–1.36) | 0.17 | 25.5 | 45.7 | 2.46 (1.54–3.99) | 0.0002 |
LCM B | ||||||||||||||
B1 | 194 | 185 | 17.5 | 13.0 | 0.67 (0.40–1.13) | 0.13 | 7.7 | 3.2 | 0.40 (0.14–1.01) | 0.06 | 25.8 | 48.6 | 2.72 (1.79–4.22) | <0.0001 |
B2 | 133 | 120 | 30.1 | 16.7 | 0.55 (0.30–0.86) | 0.01 | 8.3 | 5.0 | 0.58 (0.20–1.59) | 0.30 | 18.0 | 38.3 | 2.82 (1.60–5.08) | 0.0004 |
B3 | 68 | 63 | 19.1 | 25.4 | 1.42 (0.68–2.94) | 0.37 | 10.3 | 9.5 | 0.92 (0.28–2.92) | 0.88 | 16.2 | 30.2 | 2.24 (0.98–5.32) | 0.06 |
B4 | 131 | 127 | 33.6 | 31.5 | 0.94 (0.61–1.44) | 0.78 | 13.0 | 11.0 | 0.83 (0.39–1.76) | 0.63 | 14.5 | 18.1 | 1.30 (0.67–2.55) | 0.43 |
B5 | 37 | 63 | 62.2 | 49.2 | 0.69 (0.40–1.18) | 0.12 | 35.1 | 20.6 | 0.58 (0.19–1.19) | 0.11 | 2.7 | 15.9 | 6.79 (1.22–127.37) | 0.07 |
All | 563 | 558 | 26.8 | 23.5 | 0.82 (0.65–1.04) | 0.10 | 11.2 | 8.1 | 0.70 (0.46–1.04) | 0.08 | 18.7 | 33.7 | 2.22 (1.69–2.93) | <0.0001 |
Plac = placebo, Buc = bucindolol.