Table 4. Cox proportional hazards ratio, cumulative mortality for individual and combined models.
| Cox Multivariate HR – Cumulative all-cause mortality | |||||||
| Bucindolol | 0.82(0.65–1.04) | 0.76(0.60–0.96) | 0.77(0.61–0.97) | 0.77(0.61–0.98) | 0.78(0.62–0.99) | 0.75(0.60–0.95) | 0.76(0.60–0.96) |
| A1 | Reference | – | – | Reference | Reference | – | Reference |
| A2* Time int | 0.39(0.25–0.61) 1.92(1.04–3.51) | – | – | 0.34(0.22–0.52) | 0.50(0.32–0.79)2.00(1.07–3.74) | – | 0.48(0.30–0.75) 1.98(1.06–3.68) |
| A3 | 0.34(0.23–0.50) | – | – | 0.40(0.27–0.58) | 0.48(0.33–0.71) | – | 0.49(0.33–0.72) |
| A4* Time int | 0.35(0.22–0.56) 0.72(0.53–0.97) | – | – | 0.63(0.41–0.98) | 0.48(0.30–0.76)0.73(0.54–0.98) | – | 0.57(0.34–0.95) 0.73(0.54–0.99) |
| A5 | 0.65(0.43–0.98) | – | – | 0.64(0.42–0.97) | 0.67(0.44–1.02) | – | 0.65(0.43–0.99) |
| A6 | 0.32(0.23–0.44) | – | – | 0.41(0.29–0.59) | 0.47(0.33–0.66) | – | 0.49(0.35–0.70) |
| B1 | – | Reference | – | Reference | – | Reference | Reference |
| B2 | – | 0.63(0.44–0.90) | – | 0.69(0.47–1.02) | – | 0.75(0.52–1.08) | 0.79(0.53–1.17) |
| B3 | – | 1.41(1.01–1.96) | – | 1.28(0.92–1.79) | – | 0.97(0.69–1.37) | 0.92(0.65–1.31) |
| B4 | – | 0.93(0.60–1.45) | – | 0.94(0.57–1.54) | – | 0.76(0.49–1.19) | 0.76(0.46–1.26) |
| B5 | – | 3.25(2.24–4.71) | – | 3.02(2.08–4.40) | – | 1.58(1.04–2.42) | 1.64(1.07–2.51) |
| SHFM Score | – | – | 3.06(2.50–3.73) | – | 2.70(2.17–3.35) | 2.47(1.93–3.16) | 2.26(1.74–2.93) |
| Wald χ2 | 77.5(p<.0001) | 83.3(p<.0001) | 121.58(p<.0001) | 138.7(p<.0001) | 156.5(p<.0001) | 141.0(p<.0001) | 176.6(p<.0001) |
*
estimates represent the HR at the geometric mean of the survival times, approximately 1.8 years.