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. 2012 Nov 7;7(11):e46524. doi: 10.1371/journal.pone.0046524

Table 1. Top 20 hub chemicals, genes and disease in the CTD network.

Chemical Name (ID) Edges Gene Symbol Edges Disease Name (ID) Edges
Tetrachlorodibenzodioxin (D013749) 7176 TNF 835 Prostatic Neoplasms (D011471) 515
Acetaminophen (D000082) 6362 CASP3 581 Breast Neoplasms (D001943) 442
pirinixic acid (C006253) 5664 CYP1A1 553 Autistic Disorder (D001321) 303
Ammonium Chloride (D000643) 5271 MAPK1 551 Lung Neoplasms (D008175) 240
Ethinyl Estradiol (D004997) 5066 MAPK3 546 Liver Cirrhosis, Experimental (D008106) 230
Cyclosporine (D016572) 4601 PTGS2 521 Stomach Neoplasms (D013274) 210
Benzo(a)pyrene (D001564) 3397 IL6 517 Colorectal Neoplasms (D015179) 197
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide (D015123) 2918 IL1B 492 Craniofacial Abnormalities (D019465) 179
4,4′-diaminodiphenylmethane (C009505) 2702 CYP1A2 473 Carcinoma, Hepatocellular (D006528) 173
2,4-dinitrotoluene (C016403 2647 TP53 458 Drug-Induced Liver Injury (D056486) 167
2,6-dinitrotoluene (C023514) 2628 NOS2 456 Melanoma (D008545) 157
Estradiol (D004958) 2620 ESR1 453 Colonic Neoplasms (D003110) 126
Tamoxifen (D013629) 2259 BCL2 443 Inflammation (D007249) 124
Carbon Tetrachloride (D002251) 2237 CYP3A4 414 Liver Diseases (D008107) 122
Diethylnitrosamine (D004052) 2153 FOS 404 Liver Neoplasms (D008113) 122
Tretinoin (D014212) 1957 BAX 380 Neoplasms (D009369) 118
arsenic trioxide (C006632) 1938 CDKN1A 375 Schizophrenia (D012559) 115
sodium arsenite (C017947) 1910 HMOX1 374 Alzheimer Disease (D000544) 109
Dietary Fats (D004041) 1907 RELA 368 Leukemia, Myeloid, Acute (D015470) 107
Phenobarbital (D010634) 1831 IL8 367 Adenocarcinoma (D000230) and Seizures (D012640) 95