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. 2012 Nov 7;7(11):e46524. doi: 10.1371/journal.pone.0046524

Table 2. Disease inferences for BPA that are based on five interacting genes.

Disease (# edges) Gene Symbols (# edges) Cxy p1 p2 SXYA WXYA
Disorders of Sex Development (MESH:D012734) (5) CYP19A1 (202); HSD17B3 (27); LHB (83); LHCGR (34); NR3C1 (189) 7.48 17.21 27.02 22.04 17.10
Muscular Dystrophy, Facioscapulohumeral (MESH:D020391) (9) CDKN1A (375); DCN (49); ELN (32); HSPA1B (84); LUM (25) 5.42 12.51 27.77 20.21 12.45
Osteosarcoma (MESH:D012516) (11) CYP3A4 (414); FOLR1 (39); JUN (305); NR1I2 (216); TP53 (458) 4.88 11.27 22.54 16.91 11.38
Metabolic Syndrome X (MESH:D024821) (16) ADIPOQ (89); CCL2 (283); LEP (106); SHBG (48); TRIB3 (51) 3.96 9.19 26.30 18.36 10.27
Precancerous Conditions (MESH:D011230) (20) CCND1 (327); IRS1 (47); MAPK8 (200); MAPK9 (109); PTGS2 (521) 3.46 8.05 23.44 15.74 8.19
Myocardial Reperfusion Injury (MESH:D015428) (22) ADIPOG (89); EDN1 (186); NOS2 (456); PTEN (100); SLC8A1 (31) 3.25 7.59 25.19 16.39 7.75
Drug Hypersensitivity (MESH:D004342) (22) ABCC2 (204); HSPA1A (122); IL4 (228); IL4RA (17); TNF (835) 3.25 7.59 24.13 15.86 7.74
Limb Deformities, Congenital (MESH:D017880) (25) CACNA1C (23); FGFR2 (90); HOXA11 (22); TBX3 (21); TGFB2 (70) 2.98 6.98 30.32 18.98 7.41
Carcinoma (MESH:D002277) (25) BCL2 (443); EGFR (204); KRAS (79); PTGS2 (521); TARBP2 (11) 2.98 6.98 24.73 15.86 7.14
Endometrial Neoplasms (MESH:D016889) (34) BIRC5 (167); DCN (49); HOXA11 (22); PTEN (100); SUZ12 (13) 2.37 5.62 29.24 17.79 6.07
Cleft Lip (MESH:D002971) (28) FGFR1 (73); FGFR2 (90); FGFR3 (60); SPRY2 (19); TYMS (113) 2.75 6.46 28.09 17.28 5.83
Leukemia, Promyelocytic, Acute (MESH:D015473) (34) AKT1 (315); CD44 (70); CEBPA (78); ITGB2 (46); RARA (81) 2.37 5.62 26.32 15.97 5.81
Dermatitis, Atopic (MESH:D003876) (37) CXCL10 (87); IFNG (347); IL1B (492); IL4 (228); TSLP (18) 2.21 5.27 24.37 14.82 5.44
Neuroblastoma (MESH:D009447) (39) IFNB1 (48); MET (61); MYC (253); MYCN (31); NTRK2 (37) 2.11 5.05 28.09 16.57 5.26
Glioblastoma (MESH:D005909) (42) IL1B (492); MMP2 (194); NCOR1 (39); TGM2 (75); VEGFA (271) 1.97 4.76 24.17 14.46 4.94
Cardiovascular Diseases (MESH:D002318) (43) CBS (24); CCL2 (283); EDN1 (186); GH1 (70); VCAM1 (123) 1.93 4.67 25.86 15.27 4.86
Liver Cirrhosis (MESH:D00103) (49) CTGF (77); FGFR2 (90); MMP2 (194); SPP1 (113); THBS1 (68) 1.70 4.18 25.90 15.04 4.38
Colitis, Ulcerative (MESH:D003093) (50) GNA12 (18); IL12B (194); IL1B (492); PTPN2 (18); STAT3 (127) 1.67 4.11 26.77 15.44 4.32
Cell Transformation, Neoplastic (MESH:D002471) (60) NOS2 (456); SLC16A1 (73); SLC2A1 (88); TSC22D1 (46); WNT5A (38) 1.37 3.48 26.52 15.00 3.70
Lupus Erythematosus, Systemic (MESH:D008180) (62) CLU (115); ETS1 (35); FASLG (72); IL12B (194); IL4 (228) 1.32 3.38 25.71 14.55 3.58
Kidney Diseases (MESH:D007674) (71) CDKN1A (375); HOXA11 (22); LCN2 (64); LRP2 (19); TERT (80) 1.11 2.97 28.15 15.56 3.20