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Proband’s family tree. Patient II/2 (proband) clearly has JPS. Mutation of the BMPRA1 gene was shown in patients III/1 (proband’s niece) and III/3 (proband’s daughter), therefore they need strict endoscopic surveillance. Mutation of the BMPRA1 gene was not detected in patient III/2, therefore his risk to develop carcinoma is the same as for average people
