Figure 3. Nicotine and DHβE resulted in fewer marbles buried.

A) The 0.01 and 0.032 mg/kg i.p. nicotine that promoted anxiolytic-like behavior in the CER task also resulted in a significant reduction in digging behavior as measured by fewer marbles buried compared to when mice were administered saline (n = 14). B) Similarly, mice treated with 3 mg/kg i.p. DHβE also buried less marbles compared to when they received saline treatment (n = 15). Data are presented as means ± SEM; *p<0.05 compared to when mice received saline control injections.