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. 2012 Oct 30;27(11):1411–1417. doi: 10.3346/jkms.2012.27.11.1411

Fig. 2.

Fig. 2

Dexmedetomidine affects mechanical allodynia of vincristine treated rats. (A) The withdrawal threshold to mechanical stimuli in the vincristine-induced neuropathic rats. The withdrawal threshold was observed before (Pre) and after injection of normal saline (NS), dexmedetomidine 12.5 µg/kg (DEX12.5), dexmedetomidine 25 µg/kg (DEX25), dexmedetomidine 50 µg/kg (DEX50), dexmedetomidine 100 µg/kg (DEX100). Results are presented as mean ± standard error of mean (n = 6 in saline group, n = 7 per each dexmedetomidine group) (*P < 0.05 vs NS; †P < 0.01 vs NS; ‡P < 0.001 vs NS). (B) Dose-response curve of the percentage maximum possible effect (%MPE) on mechanical analgesia in the dexmedetomidine groups. This shows a mechanical analgesia dose-dependently. Each point is represented the mean ± standard error of mean (n = 6 in saline group, n = 7 per each dexmedetomidine group) (*P < 0.05 vs NS; †P < 0.05 vs 12.5 µg/kg; ‡P < 0.05 vs 25 µg/kg; §P < 0.05 vs 50 µg/kg of dexmedetomidine).