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. 2012 Oct 30;27(11):1411–1417. doi: 10.3346/jkms.2012.27.11.1411

Fig. 3.

Fig. 3

Dexmedetomidine reverses cold allodynia of vincristine treated rats. (A) The withdrawal frequency to cold stimuli. The frequency was measured before (Pre) and after injection of normal saline (NS), dexmedetomidine 12.5 µg/kg (DEX12.5), dexmedetomidine 25 µg/kg (DEX25), dexmedetomidine 50 µg/kg (DEX50), dexmedetomidine 100 µg/kg (DEX100). Results are presented as mean ± standard error of mean (n = 6 in saline group, n = 7 per each dexmedetomidine group) (*P < 0.05 vs NS; †P < 0.01 vs NS; ‡P < 0.001 vs NS). (B) Dose-response curve of the percentage maximum possible effect (%MPE) on cold analgesia in the dexmedetomidine groups. This shows a cold analgesia dose-dependently. Each point is represented the mean ± standard error of mean (n = 6 in saline group, n = 7 per each dexmedetomidine group) (*P < 0.05 vs NS; †P < 0.05 vs 12.5 µg/kg; ‡P < 0.05 vs 25 µg/kg of dexmedetomidine).