Respiratory |
Dyspnea, wheeze |
45 %–50 % |
Difficulty/noisy breathing |
83 % |
Upper airway angioedema |
50 %–60 % |
Wheeze |
59 % |
Rhinitis |
15 %–20 % |
Cough |
33 % |
Swelling tongue |
13 % |
Swelling/tightness in throat |
11 % |
Difficulty talking/hoarse voice |
13 % |
Cutaneous |
Urticaria, angioedema |
85 %–90 % |
Urticaria |
72 % |
Flushing |
45 %–55 % |
Angioedema |
55 % |
Pruritus without rash |
2 %–5 % |
Pruritus |
11 % |
Gastrointestinal |
Nausea, vomiting, diarrhea, cramping pain |
25 %–30 % |
Vomiting, diarrhea, abdominal cramps |
29 % |
Cardiovascular |
Dizziness, syncope, hypotension |
30 %–35 % |
Hypotension, pale and floppy, impaired/loss of consciousness, collapse |
17 % |