Table 1.

Summary of zebrafish hepatic steatosis mutants

Mutant	Gene symbol	Protein	Function	Phenotypes	Mechanisms involved in hepatic steatosis
foie gras (fgr)	trappc11	Trafficking protein particle complex 11	Involved in endoplasmic reticulum and Golgi traffic	Hepatic steatosis hepatomegally hepatocyte nuclear degeneration Lethal	Generation of endoplasmic reticulum stress. Induction of lipid biosynthetic enzyme gene expression
ducttrip (dpt)	ahcy	S-adenosyl-homocysteine hydrolase	Methyl donor metabolic enzyme	Hepatic steatosis Liver and pancreas degeneration Lethal	Induction of lipid biosynthetic enzyme and inflammatory gene expression
hi559	cdipt	Cytidine diphosphate-diacylglycerol-inositol 3-phosphatidyltrasnferase	Phospholipid synthesis	Hepatic steatosis Lethal	Endoplasmic reticulum stress Mitochondrial morphological defects
red moon (rmn)	slc16a6a	Solute carrier family 16, member 6a	β-hydroxybutyrate transporter	Fasting hepatic steatosis Viable	Failure to secrete ketone bodies causes carbon atom storage in triacylglycerol
	skt11	Serine/threonine kinase 11 (LKB1)	Phosphorylation of the nutritional-sensor AMP-kinase	Fasting hepatic steatosis Glycogen depletion Viable	Inadequate activation of Prka (AMP-activated protein kinase) causing incomplete suppression of de novo lipogenesis and cholesterol biosynthesis