Skip to main content
. 2012 Sep 11;13(11):1012–1020. doi: 10.1038/embor.2012.133

Figure 3.

Figure 3

Subcutaneous white adipose tissue is reduced in Hr mutant mouse pups. (A) Body weight, weight of brown adipose tissue (BAT), weight of subcutaneous white adipose tissue (WAT) and WAT mass to body weight ratios of 18-days-old heterozygous control (Hrwt/Hrrh) and homozygous mutant (Hrrh/Hrrh) pups. (B) Transverse histological sections (haematoxylin–eosin (H&E, left) and Oil Red O (right)) at the level of the scapula from Hrwt/Hrrh and Hrrh/Hrrh pups 4 days after birth. Black arrows indicate subcutaneous adipose tissue. Scale bars, 1mm (upper panels) and 250 μm (lower panels). (C) Relative expression of LIM homeobox 8 (Lhx8) and uncoupling protein 1 (Ucp1) in BAT and WAT of 10-week-old heterozygous control (Hrwt/Hrrh) and homozygous (Hrrh/Hrrh) mutant mice using quantitative reverse transcription–polymerase chain reaction. Error bars indicate standard deviations. *P<0.05; ***P<0.001 (n=4, Student’s t-test). HR, hairless; NS, nonsignificant.