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. 2012 Sep 25;31(21):4165–4178. doi: 10.1038/emboj.2012.266

Figure 1.

Figure 1

Enrichment profiles for ChIP-Seq analysis of CTCF, cohesin, and RNAPII binding to human subtelomeres. Fragment density profiles were generated for samples and a matched IgG control as described in Materials and methods. The fold enrichment of sample over IgG is shown. (A) CTCF, RNAPII, and Rad21 binding in the first 15 kb subtelomeres of chromosome arms 10q, 13q, 15q, and XYq. The y-axis for each track is auto-scaled to highest peak in each chromosome region shown. (B) Model enrichment profile with peaks within the first 5 kb of the telomere tract. The CTCF peak is just centromeric to the CpG-island, typically centred over a 61-mer repeat. The RNA Pol II tract is centred over the 29-mer repeat. The exact position of these peaks varies with the positioning of these genomic features relative to the start of the terminal repeat tract on each chromosome arm.