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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: Nat Genet. 2012 Oct 7;44(11):1282–1285. doi: 10.1038/ng.2427

Figure 2.

Figure 2

Measurements of the m.3875delC mutation levels in mothers, primary germ cells (PGCs), oocytes and offspring. (a) Offspring mutation levels (N=533) relative to maternal (N=44) mutation levels for the m.3875delC mutation. (b) Change in average litter mutation load over five generations from 9 individual mothers (symbols). (c) Percentage m.3875delC mutation in 819 PGCs isolated from 18 embryos at 13.5 day-post-conception (dpc) showing no evidence of selection. (d) Normalized variance in heteroplasmy levels in the PGCs, oocytes and offspring. The variance in heteroplasmy is critically dependent on the original heteroplasmy value in the single cell zygote, 3.5 P0. We therefore plotted the variance as a function of the original heteroplasmy value for the different data sets. (e) Percentage m.3875delC mutation in 340 oocytes isolated from the ovaries of five 3.5-day-old neonate females with varying mutation levels showing no evidence of selection.