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. Author manuscript; available in PMC: 2013 Oct 25.
Published in final edited form as: J Med Chem. 2012 Oct 12;55(20):8657–8670. doi: 10.1021/jm3008486

Figure 3.

Figure 3

Percentage of survival (A, B, C) and average body weight (D, E, F) of mice orally administered with various compounds at indicated concentrations and challenged with 1 × 105 (3× LD50) cell culture infectious doses (TCID50) of influenza A/CA/04/2009 (H1N1) virus. Mice were orally administered with test compounds 4 hours prior to virus challenge and every day at a 12 hour interval as indicated. The number of mice and the average weight of the mice at day 0 (10 mice per group) were defined as 100%, respectively. ***: P < 0.0001. **: P < 0.001.