Table 3.

Distribution coefficients of anti-influenza compounds between octanol and PBS buffer.

Entry	Compound	cLog Pa	cLog Db	Log Dc
1	1a (OC)	0.45	−1.84	−1.69 ± 0.16 (−1.50)d
2	1b (OS)	1.49	−0.72	(0.36)d
3	2a (GOC)	−0.22	−1.55	−1.41 ± 0.24
4	2b (GOS)	0.83	0.73	0.31 ± 0.05e
5	3a (TP)	−1.25	−2.42	−1.04 ± 0.14
6	3b (TP2Et)	2.18	−1.39	0.22 ± 0.04
7	3c (TP1Et)	−0.14	−1.52	−0.75 ± 0.10
8	4a (TPG)	−1.92	−2.17	−0.98 ± 0.18
9	4b (TPG2Et)	1.51	−1.93	−0.10 ± 0.04
10	4c (TPG1Et)	−0.81	−1.27	−0.37 ± 0.02

^aCalculated values using Advanced Chemistry Development (ACD/Labs) Software V12.01.

^bCalculated values using MarvinSketch (http://www.chemaxon.com/marvin/sketch/index.html)

^cOctanol–water partition coefficient determined at pH 7.4 from five repeated experiments.

^dLog D value at pH 7.4 (adapted from ref 20).

^eLog D value at pH 7.4 (adapted from ref 22).