Table 4.
hsa-miRNA | Predicted targets† | Validated targets of the RCC pathway‡ |
---|---|---|
miR-10b | 57 | PIK3CA, CRK, PAK7 |
miR-19a | 321 | PIK3CA, HIF1A, KRAS, PAK6, RAP1B, RAP1A, PIK3R3, RAF1 |
miR-19b | 326 | PIK3CA, HIF1A, KRAS, PAK6, RAP1B, RAP1A, PIK3R3, RAF1 |
miR-20a | 293 | HIF1A, EGLN3, EPAS1, VEGFA, CRK, MAPK1, PAK7, EGLN1 |
miR-21 | 67 | PIK3R1 |
miR-26a | 206 | HGF, CREBBP, PAK2, RAP1B, RAP1A, EP300 |
miR-29a | 281 | PDGFB, PIK3R1, VEGFA, CDC42, PIK3R2, ARNT, AKT3, TGFB3 |
miR-29b | 284 | PDGFB, PIK3R1, VEGFA, CDC42, PIK3R2, AKT3 |
miR-29c | 315 | PDGFB, PIK3R1, VEGFA, CDC42, PIK3R2, ARNT, AKT3, TGFB3 |
miR-100 | 15 | - |
miR-101 | 188 | TCEB1, MAPK1, RAC1, PAK2, RAP1B, AKT2, PAK7 |
miR-126 | 4 | CRK |
miR-127 | 4 | - |
miR-130a | 233 | MET, EGLN3, SOS1, PAK6, EP300 |
miR-141 | 168 | HGF, CDC42, GRB2, TGFB2, GAB1 |
miR-143 | 74 | KRAS, PTPN11, EGLN1 |
miR-145 | 101 | PAK7 |
miR-148a | 166 | MET, SLC2A1, EPAS1, SOS1, EP300, PIK3R3 |
miR-155 | 96 | PIK3CA, HIF1A, KRAS, SOS1, RAP1B, ETS1 |
miR-192 | 19 | - |
miR-194 | 74 | HIF1A, MAPK1, RAP1B, AKT2 |
miR-200c | 289 | TCEB1, CRKL, SOS1, PTPN11, VEGFA, RAC1, RAP1B, ETS1, PAK7, EP300, EGLN1, JUN |
miR-210 | 4 | - |
miR-215 | 19 | RAP1B |
miR-223 | 58 | PAK7 |
miR-224 | 82 | ETS1 |
miR-296 | 1050 | - |
miR-370 | 132 | PIK3CA, SOS1 |
miR-514 | 550 | RBX1, SLC2A1, JUN, AKT3 |
miR-638 | 254 | - |
†Number of predicted targets according to the algorithms explained in Materials and Methods. The individual targets are available as complete list upon request. ‡Validated targets indicated by the software DIANA-mirPath (http://diana.cslab.ece.ntua.gr) corresponding to the genes that were provided to be affected in the renal cell carcinoma pathway as shown in the KEGG database 27.