Table 4.

Predicted and validated targets of the differentially expressed miRNAs in this study.

hsa-miRNA	Predicted targets†	Validated targets of the RCC pathway‡
miR-10b	57	PIK3CA, CRK, PAK7
miR-19a	321	PIK3CA, HIF1A, KRAS, PAK6, RAP1B, RAP1A, PIK3R3, RAF1
miR-19b	326	PIK3CA, HIF1A, KRAS, PAK6, RAP1B, RAP1A, PIK3R3, RAF1
miR-20a	293	HIF1A, EGLN3, EPAS1, VEGFA, CRK, MAPK1, PAK7, EGLN1
miR-21	67	PIK3R1
miR-26a	206	HGF, CREBBP, PAK2, RAP1B, RAP1A, EP300
miR-29a	281	PDGFB, PIK3R1, VEGFA, CDC42, PIK3R2, ARNT, AKT3, TGFB3
miR-29b	284	PDGFB, PIK3R1, VEGFA, CDC42, PIK3R2, AKT3
miR-29c	315	PDGFB, PIK3R1, VEGFA, CDC42, PIK3R2, ARNT, AKT3, TGFB3
miR-100	15	-
miR-101	188	TCEB1, MAPK1, RAC1, PAK2, RAP1B, AKT2, PAK7
miR-126	4	CRK
miR-127	4	-
miR-130a	233	MET, EGLN3, SOS1, PAK6, EP300
miR-141	168	HGF, CDC42, GRB2, TGFB2, GAB1
miR-143	74	KRAS, PTPN11, EGLN1
miR-145	101	PAK7
miR-148a	166	MET, SLC2A1, EPAS1, SOS1, EP300, PIK3R3
miR-155	96	PIK3CA, HIF1A, KRAS, SOS1, RAP1B, ETS1
miR-192	19	-
miR-194	74	HIF1A, MAPK1, RAP1B, AKT2
miR-200c	289	TCEB1, CRKL, SOS1, PTPN11, VEGFA, RAC1, RAP1B, ETS1, PAK7, EP300, EGLN1, JUN
miR-210	4	-
miR-215	19	RAP1B
miR-223	58	PAK7
miR-224	82	ETS1
miR-296	1050	-
miR-370	132	PIK3CA, SOS1
miR-514	550	RBX1, SLC2A1, JUN, AKT3
miR-638	254	-

^†Number of predicted targets according to the algorithms explained in Materials and Methods. The individual targets are available as complete list upon request. ^‡Validated targets indicated by the software DIANA-mirPath (http://diana.cslab.ece.ntua.gr) corresponding to the genes that were provided to be affected in the renal cell carcinoma pathway as shown in the KEGG database ²⁷.