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. 2012 Nov 1;8(10):1385–1397. doi: 10.7150/ijbs.5141

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© Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.

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Fig 9 — Function of Csk as a tumor suppressor. (A) Effect of Csk overexpression on tumor growth. Human colon cancer cell line HT29, HT29 expressing wild-type Csk (HT29/Csk) and HT29 expressing kinase-negative Csk (HT29/CskKN) were injected s.c. into nude mice. Tumor volume (cm³) obtained from four mice is plotted versus days after inoculation. Excised tumors are shown in lower panel. (B) Tumor incidence in wild-type and heterozygous for Csk (csk^+/-) and p53 (p53^+/-) after the sequential treatment of skin with dimethyl benzanthracene (DMBA) and phorbol myristate acetate (TPA).