Table 2.
Prognostic significance of AF in STEMI patients
| Study | Risk of mortality | |
|---|---|---|
| In-hospital/30-day/90-day | ≥1-year | |
| GUSTO I2 | ||
| Any AF | 30-day *OR 1.3 (1.2-1.4) | 1-year n.a. Kaplan-Meier estimates: 21.5 vs 8.4%, p<0.001 |
| Prior AF | 30-day *ns | 1-year n.a. Kaplan-Meier estimates: 22.2 vs 8.4%,p<0.001 |
| New-onset AF | 30-day *OR 1.4 (1.3-1.5) | 1-year n.a. Kaplan-Meier estimates: 21.2 vs 8.4%,p<0.001 |
| GUSTO III8 | ||
| New-onset AF | 30-day **OR 1.49 (1.17-1.89) | 1-year **OR 1.64 (1.35-2.01) |
| GISSI9 | ||
| New-onset AF | In-hospital *RR 1.98 (1.67-2.34) | 4-year *RR 1.78 ( 1.6-1.99) |
| TRACE10 | ||
| Any AF | In-hospital *OR 1.5 (1.2-1.9) | 5-year *RR 1.3 (1.2-1.4) |
| Prior AF | In-hospital *OR 1.2 (0.8-1.9) n.s. | 5-year *RR 1.3 (1.2-1.4) |
| New-onset AF | In-hospital *OR 1.5 ( 1.2-1.9) | 5-year *RR 1.4 (1.2-1.7) |
| OPTIMAAL11 | ||
| Prior AF | 30-day n.s. | 3-year *HR 1.32 (1.13-1.56) |
| New-onset AF | 30-day *HR 3.83(1.97-7.43) | 3-year *HR 1.82 (1.39-2.39) |
| VALIANT12 | ||
| Any AF | - | 3-year *HR 1.3 (1.19-1.43) |
| Prior AF | - | 3-year *HR1.25 (1.03-1.54) |
| New-onset AF | - | 3-year *HR1.32 (1.2-1.45) |
| OACIS4 | ||
| Any AF | In-hospital *HR 1.42 (0.88-2.31) n.s. | 1-year *HR 1.64 (1.05-2.55) |
| Prior AF | In-hospital *n.s. | 1-year *HR 1.87 (0.45-7.52) n.s. |
| New-onset AF | In-hospital *n.s. | 1-year *HR 3.04(1.24-7.48) |
| APEX-MI15 | ||
| New onset AF | 90-day HR**1.81(1.06-3.09) | - |
*
adjustment for baseline clinical variables, treatment
**
adjustment for baseline clinical variables and in-hospital complications pre-AF
95% confidence intervals are presented in brackets, HR – hazard ratio, OR – odds ratio, RR – relative risk, n.a. – not available, n.s. – not significant