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. 2012 Sep 12;303(10):C1045–C1054. doi: 10.1152/ajpcell.00020.2012

Fig. 5.

Fig. 5.

Effects of MGO on the coding region of the Kir6.1 and SUR2B mRNAs. Kir6.1 and SUR2B mRNAs were synthesized by in vitro transcription and treated with different concentrations of MGO. A and B, top: gel image of SUR2B and Kir6.1 mRNAs treated with 100, 300, and 600 μM MGO, respectively, along with sham-treated mRNA as control for 18 h. A and B, bottom: vertical elongation images of SUR2B and Kir6.1 gel images from the corresponding top. RNA band sizes on the RNA marker are labeled at left. C: summary of normalized quantity (NQ) of SUR2B mRNA following MGO treatment (100, 300, and 600 μM) for 18 h. D: summary of NQ of SUR2B mRNA treated with 300 μM MGO for different time periods (6, 18 and 24 h). E: summary of NQ of Kir6.1 mRNA following MGO treatment (100, 300, and 600 μM) for 18 h. F: summary of NQ of Kir6.1 mRNA treated with 300 μM MGO for different time points (6, 18, and 24 h). ***P < 0.001 (n = 4 experiments).