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. 2012 Sep 19;303(10):C1079–C1089. doi: 10.1152/ajpcell.00162.2012

Fig. 1.

Fig. 1.

Phosphodiesterase 1 (PDE1) inhibition with 8-methoxymethyl-3-isobutyl-1-methylxanthine (8MM-IBMX) increases the cAMP levels in guinea pig detrusor smooth muscle (DSM). Summary data showing that 8MM-IBMX (10 μM) increased the total cAMP levels and nonselective PDEs inhibition with IBMX (10 μM) increased cAMP to a higher level in guinea pig DSM. cAMP was measured using enzyme immunoassay. Data were obtained from 4 strips each from a different guinea pig and all measurements were in duplicates. (n = 4, N = 4; *P < 0.05 vs. control; #P < 0.05 vs. 8MM-IBMX).