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. 2012 Nov 7;448(Pt 2):189–200. doi: 10.1042/BJ20120339

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© 2012 The Author(s) The author(s) has paid for this article to be freely available under the terms of the Creative Commons Attribution Non-Commercial Licence (http://creativecommons.org/licenses/by-nc/2.5/) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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(a) Monovalent CatSper currents recorded before (black trace) and after (grey trace) application of 5 μM (left-hand panel) and 100 μM (right-hand panel) 2-APB. Horizontal (near zero) traces show currents in divalent cation-containing saline. (b) Time course of CatSper current block by 100 μM 2-APB. Cell conductance was calculated from the slope between +50 and +60 mV. Grey shading shows superfusion with DVF saline, arrow shows application of 2-APB. (c) 2-APB does not raise pH_i. 2-APB at 5 and 15 μM was added at the first and second arrows respectively. 4-Aminopyridine (2 mM; 4-AP; positive control) caused an immediate rise in pH_i. (d) Mean pH_i change (±S.E.M.) in response to 5 μM (n=6), 15 μM (n=3) and 50 μM (n=3) 2-APB.