Figure 6. 2-APB modifies the sustained [Ca²⁺]_i elevation.

(a) 2-APB (5 μM) was applied to cells already stimulated with 3 μM progesterone (prog). 2-APB caused a tonic increase in [Ca²⁺]_i that reversed upon washout (↑) of the drug. Traces show PHN responses from seven individual representative cells. (b) 2-APB (50 μM) was applied to cells already stimulated with 3 μM progesterone. Upon application of the drug, [Ca²⁺]_i fell and oscillations were suppressed, but [Ca²⁺]_i then recovered despite the continued presence of the drug. Traces show PHN responses from six individual representative cells.