Fig. 4.

Biosynthesis of the LPS of Y. pestis [22, 32–34]. (A) Enzymes of the LPS core synthesis and the late stages of the lipid A synthesis. R represents 3‑hydroxymyristoyl. (B) Organization of the gene clusters for the LPS core synthesis. The genes in the clusters waaI (YP0054-YP0058), waaII (YP0416-YP0417), and wab (YP0186-YP0187) and the corresponding glycosyl transferases are shown in light gray, dark gray, and black, respectively. The functions of the glycosyl transferases genes are assigned based on the analysis of available Y. pestis full genome sequences and the data on LPS structure in knockout mutants at each gene. The figure is reproduced from the paper of the authors [32] with the permission of the Nauka Publishing Company.