. Author manuscript; available in PMC: 2012 Nov 8.

Published in final edited form as: J Am Chem Soc. 2011 Oct 4;133(42):16746–16749. doi: 10.1021/ja206312b

Table 1.

K_i or IC₅₀ values (μM) of methyltransferase inhibitors.^a,^b

	DOT1L	CARM1	PRMT1	G9a	SUV39H1
SAH^a	0.16	0.40	0.86	0.57	4.9
1 ^a	0.29	>100	22.7	>100	>100
2 ^a	1.1	18	21.2	>100	>100
3 ^b	15.7	46.4	22.0	>100	>100
4 ^b	0.038	1.1	2.7	1.8	>100
5 ^b	0.12	>100	>100	>100	>100
6 ^b	0.11	>100	>100	>100	>100

K_i values for competitive inhibitors SAH, 1 and 2;

IC₅₀ values for inhibitors 3 – 6.