Table 2.
Therapeutic significance of VGCCs (Triggle, 2007; Mohan and Gandhi, 2008; Bingham et al., 2010)
| Systematic name | Current | Expression | Therapeutic significance |
|---|---|---|---|
| Cav1.1 | L | Skeletal muscle | – |
| Cav1.2 | L | Cardiac muscle, endocrine cells and neurons | Cardiovascular disorders |
| Cav1.3 | L | Endocrine cells and neurons | Parkinson's disease, cardiac arrhythmia |
| Cav1.4 | L | Retina | |
| Cav2.1 | P Q | Dendrites and nerve terminals | Epilepsy, migraine |
| Cav2.2 | N | Dendrites and nerve terminals | Pain |
| Cav2.3 | R | Cell bodies, dendrites and nerve terminals | Diabetes |
| Cav3.1 | T | Cardiac muscle, skeletal muscle and neurons | Cardiac arrhythmia, epilepsy, hypertension, sleep disorders |
| Cav3.2 | T | Cardiac muscle and neurons | Pain, epilepsy |
| Cav3.3 | T | Neurons | Sleep disorders, epilepsy |