Table 3.

ω-Conotoxin sequences and their corresponding VGCC subtype selectivity

Species	Name	Sequence	VGCC target	Reference/s
Conus geographus	GVIA	---CKSOGSSC---SOTSYNCC-RSCNOYTKRCY*	Cav2.2	Olivera et al. (1984); Rivier et al. (1987); Kim et al. (1995); Lew et al. (1997); Nielsen et al. (2000); Schroeder and Lewis (2006)
	GVIB	---CKSOGSSC---SOTSYNCC-RSCNOYTKRCYG*	ND	Olivera et al. (1985)
	GVIC	---CKSOGSSC---SOTSYNCC-RSCNOYTKRC*	ND	Olivera et al. (1985)
	GVIIA	---CKSOGTOC---SRGMRDCC-TSCLLYSNKCRRY*	ND	Olivera et al. (1985)
	GVIIB	---CKSOGTOC---SRGMRDCC-TSCLSYSNKCRRY*	ND	Olivera et al. (1985)
Conus magus	MVIIA	---CKGKGAKC---SRLMYDCCTGSC--RSGKC*	Cav2.2	Olivera et al. (1985; 1987); Kim et al. (1995); Nadasdi et al. (1995); Nielsen et al. (1999a,b; 2000); Schroeder and Lewis (2006)
	MVIIB	---CKGKGASC---HRTSYDCCTGSC--NRGKC*	Cav2.1	Olivera et al. (1987)
	MVIIC	---CKGKGAPC---RKTMYDCCSGSC-GRRGKC*	Cav2.1 and Cav2.2	Hillyard et al. (1992); Nielsen et al. (1999a,b); Sato et al. (2000a)
	MVIID	---CQGRGASC---RKTMYNCCSGSC--NRGRC*	Cav2.1 and Cav2.2	Monje et al. (1993)
Conus catus	CVIA	---CKSTGASC---RRTSYDCCTGSC--RSGRC*	Cav2.2	Lewis et al. (2000)
	CVIB	---CKGKGASC---RKTMYDCCRGSC--RSGRC*	Cav2.1 and Cav2.2	Lewis et al. (2000)
	CVIC	---CKGKGQSC---SKLMYDCCTGSC-SRRGKC*	Cav2.1 and Cav2.2	Lewis et al. (2000)
	CVID	---CKSKGAKC---SKLMYDCCSGSCSGTVGRC*	Cav2.2	Lewis et al. (2000); Nielsen et al. (2000); Schroeder and Lewis (2006)
	CVIE	---CKGKGASC---RRTSYDCCTGSC--RSGRC*	Cav2.2	Berecki et al. (2010)
	CVIF	---CKGKGASC---RRTSYDCCTGSC--RLGRC*	Cav2.2	Berecki et al. (2010)
Conus striatus	SVIA	---CRSSGSOC----GVTSICC-GRC--YRGRCT*	Poor specificity to mammalian VGCCs	Ramilo et al. (1992)
			Rapid paralysis and death in fish
	SVIB	---CKLKGQSC---RKTSYDCCSGSC-GRSGKC*	Cav2.1 and Cav2.2	Ramilo et al. (1992)
	SO3	---CKAAGKPC---SRIAYNCCTGSC--RSGKC*	Cav2.2	Wen et al. (2005; 2006)
Conus tulipa	TVIA	---CLSOGSSC---SOTSYNCC-RSCNOYSRKCR*	Cav2.2	Wang et al. (1998)
Conus radiatus	RVIA	---CKPOGSOC---RVSSYNCC-SSCKSYNKKC*	Cav2.2	Miljanich et al. (1991)
Conus consors	CnVIIA	---CKGKGAOC---TRLMYDCCHGSCSSSKGRC*	Cav2.2	Favreau et al. (2001)
Conus pennaceus	PnVIA	--GCLEVDYFCGIPFANNGLCCSGNC---VFVCTPQ*	Blocks molluscan HVA VGCCs	Kits et al. (1996)
	PnVIB	DDDCEPPGNFC-GMIKIGPPCCSGWC---FFACA*	Blocks molluscan HVA VGCCs	Kits et al. (1996)
Conus textile	TxVII	---CKQADEPC---DVFSLDCCTGIC---LGVCMW*	Cav1	Fainzilber et al. (1996); Kobayashi et al. (2000)
Conus fulmen	FVIA	---CKGTGKSC---SRIAYNCCTGSC--RSGKC*	Cav2.2	Lee et al. (2010)

^*C-terminal amidation.

ND, not determined.