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. 2012 Nov;167(5):1048–1061. doi: 10.1111/j.1476-5381.2012.02037.x

Figure 6.

Figure 6

Tubulysin A (TubA), pretubulysin (Prt) and Prt derivatives inhibit in vitro polymerization of tubulin. Purified tubulin was allowed to polymerize in vitro alone or in the presence of selected concentrations of TubA, Prt and Prt derivatives. Changes in relative absorption correlate to tubulin polymerization. Compounds with similar potency are grouped together (left, middle and right panel).