Figure 7.

(A) MuDelta (10 −100 mg·kg⁻¹) inhibited upper GI transit in a mouse model of post-inflammatory altered bowel function more potently at 10 mg·kg⁻¹ compared with age-matched mice that did not receive intracolonic oil of mustard (n = 12–14 per group). (B) Dose-dependent inhibition of upper GI transit by MuDelta (25–100 mg·kg⁻¹) and loperamide (1–5 mg·kg⁻¹) in the same mice 4 weeks after intracolonic mustard oil (n = 11–14 per group). (C) MuDelta (1.0 µM) decreased neurogenic secretion in the colon and small bowel of mice in both the colon (control n = 29; MuDelta n = 10) and jejunoileum (control n = 35; MuDelta n = 11).