Skip to main content
. 2012 Nov;167(5):1148–1160. doi: 10.1111/j.1476-5381.2012.02077.x

Figure 2.

Figure 2

GPCR and PKC signalling were involved in the NPY-mediated depressor effects in the NTS. (A–C) Experimental recordings illustrate the cardiovascular effects and graphs show the hypotensive effects of NPY (4.65 pmol), and the effects of pre-treatment (10 min) of the NTS with BIBP3226 (60 pmol), a selective non-peptide NPYY1 receptor antagonist, PTX (60 pmol) and GF109003X (3 pmol), a PKC inhibitor. The NPY-mediated suppression of mean blood pressure(MBP) and heart rate (HR) was significantly blocked by BIBP3226, PTX and GF109003X. Values are shown as means ± SEM, n= 6. *P < 0.05 significantly different from control group.