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NKT cells are potent immunoregulatory cells that can drive both antitumor immune responses and protect against autoimmunity. NKT cells can produce both Th1 & Th2 cytokines. Classic NKT cell agonists are highlighted. α-GalCer induces the production of both Th1 & Th2 cytokine profiles, while–OCH results in primarily Th2 and c-GalCer stimulates Th1 responses. NKT, natural killer T.
