Table I.

microRNAs as biomarkers for chemoresistance in NSCLC and SCLC.

miRNA	Cancer type	miRNA intracellular levels	Protein target	Drug	Biomarker or confirmed in resistance	Ref.
−21	NSCLC	Increased	PTEN	N/A	B	32
−21, −23b	NSCLC	Increased	TKR	Erlotinib, sunitinib, vandetanib	R	34,35
−92a−2, −147, −574−5p	SCLC	Increased	N/A	Platinum	R	30
−98, −192, −424	NSCLC	Increased	N/A	Docetaxel	B	31
−194, −200b, −212	NSCLC	Decreased	N/A	Docetaxel	B	32
−221, −222	NSCLC	Increased	Kit, p27, PTEN, TIMP3	TRAIL	B	36
−424	NSCLC	Decreased	N/A	Erlotinib, vandetanib	R	34

NSCLC, non-small cell lung cancer; SCLC, small cell lung cancer; B, biomarker; R, resistance.