Table II.

Pathways potentially active in the transition from benign to malignant prostate tissue and during surgical castration based on gene-expression differences.^a

		P-value
Pathway	Database	Benign tissue vs. cancer	Castrated tissue vs. benign tissue
AP-1_transcription_factor_network	PID	0.007	<0.001
Beta1_integrin_cell_surface_interactions	PID	<0.001
Bevacizumab_Pathway	SMPDB	0.006
Cholesterol_biosynthesis	Wikipathways		<0.001
Cholesterol_biosynthesis	Reactome		0.002
cholesterol_biosynthesis_I	HumanCyc		0.003
cholesterol_biosynthesis_II_(via_24,25-dihydrolanosterol)	HumanCyc		0.003
cholesterol_biosynthesis_III_(via_desmosterol)	HumanCyc		0.003
Collagen_adhesion_via_alpha_2_beta_1_glycoprotein	Reactome	0.001	<0.001
ECM-receptor_interaction_-_Homo_sapiens_(human)	KEGG	<0.001
Fatty_Acyl-CoA_Biosynthesis	Reactome		0.007
Focal_Adhesion	Wikipathways	0.004
Focal_adhesion_-_Homo_sapiens_(human)	KEGG	0.003
GPCR_signalling-cholera_toxin	INOH	0.004	0.003
GPCR_signalling-G_alpha_i	INOH		0.006
GPCR_signalling-pertussis_toxin	INOH		0.006
HIF-1-alpha_transcription_factor_network	PID		0.008
Immunoregulatory_interactions_between_a_ Lymphoid_and_a_non-Lymphoid_cell	Reactome	<0.001	<0.001
Integrin	INOH	0.006
Integrins_in_angiogenesis	PID	0.004
Ketogenesis	HumanCyc		0.006
Neurophilin_interactions_with_VEGF_and_VEGFR	Reactome	0.005
Platelet_degranulation_	Reactome	0.006
Prostaglandin_Synthesis_and_Regulation	Wikipathways	0.007
Protein_digestion_and_absorption_-_Homo_ sapiens_(human)	KEGG	0.002
Response_to_elevated_platelet_cytosolic_Ca2+	Reactome	0.007
Signalling_by_PDGF	Reactome	<0.001
Signalling_by_VEGF	Reactome	0.008
Smooth_Muscle_Contraction	Reactome	0.003
Steroid_Biosynthesis	SMPDB		<0.001
Steroid_biosynthesis_-_Homo_sapiens_(human)	KEGG		0.002
Superpathway_of_cholesterol_biosynthesis	HumanCyc		<0.001
Syndecan-1-mediated_signalling_events	PID	0.001
Valine_degradation_I	HumanCyc		0.009
Vatalanib_Pathway	SMPDB	0.006
VEGF_ligand-receptor_interactions	Reactome	0.008

^aThe active pathways identified and the respective P-values were produced using Chipster software. Databases used for the identification of the pathways are presented.

PID, pathway interaction database; SMPDB, small molecule pathway database; KEGG, Kyoto encyclopedia of genes and genomes; INOH, integrating network objects with hierarchies.