Figure 2.

Effects of metformin, DMSO (as a vehicle for compound C experiments; 0.8%), compound C (Comp C), and metformin (Met; 3 mM) + Comp C (10 μM) on endothelial cell proliferation evaluated by the MTT assay. HUVECs, seeded at 3×10³ cells/well, were incubated at the indicated concentrations of drugs for 72 h and then exposed to the MTT solution. Data are expressed as the mean ± SD of the percentage of control values from six independent experiments. ^***P<0.001 vs. 0 mM metformin (control); ^aP<0.001 vs. DMSO (control); ^bP<0.01 vs. metformin 3 mM.