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. 2012 Jan 12;5(4):1068–1074. doi: 10.3892/mmr.2012.753

Figure 3.

Figure 3

Figure 3

Metformin inhibits endothelial cell migration in a ‘wound’ repair model. (A) Photomicrographs (x40 magnification) showing confluent HUVECs after mechanical scraping with a pipette tip and the migration of cells into the scraped area after treatment with the medium alone (control) or with metformin (1–3 mM) or with metformin (3 mM) + compound C (10 μM). (B) Quantitation of the inhibition of HUVEC migration by metformin in the absence and presence of compound C. Data are expressed as a percentage of the migration in the untreated endothelial cells (mean ± SD) from six independent experiments. ***P<0.001 vs. 0 mM metformin (control); #P<0.01 and aP<0.001 vs. DMSO (control); bP<0.01 vs. metformin 3 mM.