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CDK inhibitors alter the expression profiles of polyamine metabolic regulators. (A) Immunoblotting assay was employed to determine the modulation of biosynthetic and catabolic pathway key enzymes ODC, SSAT and PAO, following treatment with CDK inhibitors in Caco-2 cells. (B) Total polyamine content was determined following treatment with CDK inhibitors in Caco-2 cells by HPLC.
