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. Author manuscript; available in PMC: 2013 Mar 27.
Published in final edited form as: Nature. 2012 Sep 9;489(7417):581–584. doi: 10.1038/nature11353

Figure 4. Model for Fun30/SMARCAD1 control of end resection through DSB-associated nucleosomes.

Figure 4

Fun30/SMARCAD1 weaken histone-DNA interactions in nucleosomes flanking DSBs, which facilitates ssDNA production by the Exo1- and Sgs1/Top3/Rmi1 (STR)-Dna2 resection machineries. In the absence of Fun30/SMARCAD1 histone-DNA interactions limit the extent of resection, but plasmid-based overexpression of yeast or human Exo1 (pExo1), respectively, bypasses this impediment.