Table 2.
Functional gene set analysis in high- and low-risk disease samples
| Pathways–gene sets | ||
|---|---|---|
| GSA | Up-regulated in high-risk group | Up-regulated in low-risk group |
| VEGF signaling pathway | TGF-b signaling pathway | |
| Phospholipase C signaling pathway | CD40L signaling pathway | |
| Shh pathway | TNF/stress-related signaling | |
| Trka receptor signaling pathway | Role of EGF receptor transactivation by GPCRs in cardiac hypertrophy | |
| Signal transduction through IL1R | ||
| NF-kB signaling pathway | ||
| Downregulated in high-risk group | Downregulated in low-risk group | |
| Basal transcription factors | Cell cycle: G1/S check point | |
| TNFR2 signaling pathway | ||
GSA demonstrated pathways that were statistically, significantly differentially expressed in either high- or low-risk patients (Effron–Tibshirani GSA, P < 0.05). Selected pathways of interest are shown in this table. The full list of these pathways is found in the supplementary data.
EGF, endothelial growth factor; GSA, gene set analysis; Shh, Sonic Hedgehog; TGF-b, transforming growth factor-beta; VEGF, vascular endothelial growth factor; GPCR, G protein-coupled receptor; TNFR2, tumour necrosis factor receptor.