Table 2.
gpt Mutant Fractions in Liver of gpt Delta B6C3F1 Mice 10 Weeks After Treatment With DMSO or AFB1
| Treatment | Animal no. | Sex | CMR colonies (X106) | 6-TGR colonies | Mutant fraction (X10–5) | Mean ± SD (X10–6) |
|---|---|---|---|---|---|---|
| DMSO | 110 | M | 1.90 | 21 | 1.11 | 12.5 ± 2.3 |
| 111 | M | 1.07 | 12 | 1.12 | ||
| 112 | M | 1.32 | 20 | 1.51 | ||
| 113 | F | 1.18 | 17 | 1.44 | 10.0 ± 4.7 | |
| 114 | F | 3.18 | 16 | 0.50 | ||
| 115 | F | 1.40 | 17 | 1.22 | ||
| AFB1 | 103 | M | 0.71 | 121 | 17.0 | 183 ± 19 |
| 105 | M | 1.51 | 286 | 19.0 | ||
| 131 | M | 1.53 | 315 | 20.5 | ||
| 132 | M | 0.49 | 78 | 15.8 | ||
| 133 | M | 1.07 | 206 | 19.3 | ||
| 101 | F | 0.87 | 109 | 12.5 | 191 ± 40 | |
| 102 | F | 1.97 | 433 | 22.0 | ||
| 120 | F | 2.39 | 443 | 18.5 | ||
| 122 | F | 1.26 | 260 | 20.6 | ||
| 130 | F | 1.03 | 227 | 22.1 | ||
| Note. CMR = chloramphenicol resistant; 6-TGR = 6-thioguanine resistant. | ||||||