Table 4.
Spi Mutant Fractions in Liver of gpt Delta B6C3F1 Mice 3 Weeks After Treatment With DMSO or AFB1
| Treatment | Animal no. | Sex | Plaques (X106) | Plaques (P2) (Spi–) | Mutant fraction (X10–5) | Mean ± SD (X10–6) |
|---|---|---|---|---|---|---|
| DMSO | 6 | M | 0.78 | 1 | 0.13 | 1.8 ± 0.9 |
| 9 | M | 0.75 | 2 | 0.28 | ||
| 12 | M | 0.88 | 2 | 0.24 | ||
| 15 | M | 1.09 | 1 | 0.09 | ||
| 7 | F | 1.03 | 2 | 0.19 | 3.4 ± 1.5 | |
| 8 | F | 1.15 | 4 | 0.35 | ||
| 10 | F | 1.10 | 6 | 0.55 | ||
| 20 | F | 1.12 | 3 | 0.27 | ||
| AFB1 | 23 | M | 1.03 | 30 | 2.96 | 33.8 ± 14 |
| 34 | M | 0.32 | 12 | 3.77 | ||
| 26 | M | 0.61 | 31 | 5.04 | ||
| 30 | M | 0.46 | 8 | 1.75 | ||
| 22 | F | 1.57 | 52 | 3.38 | 34.3 ± 9.7 | |
| 25 | F | 1.34 | 54 | 4.00 | ||
| 32 | F | 1.01 | 16 | 2.09 | ||
| 35 | F | 1.54 | 65 | 4.25 |