Table 5.
Spi Mutant Fractions in Liver of gpt Delta B6C3F1 Mice 10 Weeks After Treatment With DMSO or AFB1
| Treatment | Animal no. | Sex | Plaques (X106) | Plaques (P2) (Spi–) | Mutant fraction (X10–5) | Mean ± SD (X10–6) |
|---|---|---|---|---|---|---|
| DMSO | 110 | M | 2.26 | 2 | 0.09 | 3.4 ± 3.6 |
| 111 | M | 2.14 | 4 | 0.19 | ||
| 112 | M | 0.53 | 4 | 0.75 | ||
| 113 | F | 2.11 | 12 | 0.57 | 4.9 ± 3.8 | |
| 114 | F | 2.40 | 2 | 0.08 | ||
| 115 | F | 1.91 | 16 | 0.84 | ||
| AFB1 | 103 | M | 0.69 | 58 | 8.37 | 81.0 ± 13.5 |
| 105 | M | 0.57 | 59 | 10.30 | ||
| 131 | M | 1.45 | 112 | 7.71 | ||
| 132 | M | 1.02 | 71 | 6.94 | ||
| 133 | M | 0.82 | 59 | 7.18 | ||
| 101 | F | 0.97 | 42 | 4.35 | 77.1 ± 38.9 | |
| 102 | F | 0.62 | 22 | 3.58 | ||
| 120 | F | 3.14 | 160 | 5.09 | ||
| 122 | F | 0.98 | 72 | 7.32 | ||
| 130 | F | 0.72 | 95 | 13.2 |