Fig. 2.

Chromosomal damage in response to pro-oxidants. Dose-response relationships of hydrogen peroxide (H₂O₂), potassium bromate (KBrO₃), and menadione in the AHH-1 cell line with respect to micronucleus frequency. Hockey-stick statistical modeling analysis has been applied to each data set to calculate the IP, probability for nonlinearity (p), and Y-intercept. (A) H₂O₂, threshold, IP = 10.88µM, lower IP/CI = 5.93µM, Y = 1.32, and p = 0.023. (B) KBrO₃, threshold, IP = 0.35mM, lower IP/CI = 0.22mM, Y = 1.05, and p = 0.002. (C) Menadione, linear, and p = 0.35. Mn/Bn%:Percentage of binucleated cells containing one or more MN.