Table 3.

Associations of Medical Conditions With Risk of Benign Prostatic Hyperplasia, Prostate Cancer Prevention Trial, 1993–2003

Indication for NSAID Use	No. of BPH Events	Person-Years of Follow-up	Hazard Ratio for BPHa	95% Confidence Interval	P Value
Inflammation-related chronic musculoskeletal conditions
Arthritis
Yes	72	1,720	1.77	1.37, 2.29	<0.0001
No	399	23,645	1.00
Chronic musculoskeletal pain
Yes	42	1,099	1.57	1.14, 2.17	0.006
No	429	24,267	1.00
Non-inflammation-related musculoskeletal conditions
General musculoskeletal complaints
Yes	85	3,510	1.01	0.79, 1.28	0.95
No	386	21,855	1.00
Neurologic conditions
Headaches
Yes	74	2,574	1.40	1.09, 1.80	0.008
No	397	22,792	1.00
Pinched nerve/sciatica
Yes	8	357	0.83	0.41, 1.67	0.60
No	463	25,007	1.00

Abbreviation: BPH, benign prostatic hyperplasia.

^a Adjusted for age, race/ethnicity, and body mass index.