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. 2012 Oct 18;2(10):1010–1019. doi: 10.7150/thno.4924

Figure 4.

Figure 4

MR images of the representative tumors from the two groups showed the evolving tumor volume growth as well as the intratumoral necrosis. On day 0, a hyper-intense rim can be seen surrounding the hypo-intense necrotic tumor. As compared with the CA4P control group, tumor growth in 131I-Hyp was much slower with intratumoral necrosis remained or even outstretched till 12 days. Photomicrographs of 5 µm tumor sections sampled from the interface between necrotic (N) and viable tumor cells (V) was shown (A, B). In CA4P control group (A), the viable and dead cells, new vessels coexisted. Ionizing irradiation of tumor cells exposed to 131I-Hyp caused marked cell death, characterized by cell membrane damage and extensive tumor damage (B). On 12 days post 131I-Hyp, foci of radiation induced cell death was seen inside the viable tumor rim in MR images (red arrow), which was in correspondence with nests of relative high radioactivity in autoradiogram of the same section(C). Liver (L) showed much lower radioactivity as compared with the viable tumor (V) and the intratumoral necrosis (N)