Figure 5.

Typical patterns of Hyp uptake in necrotic tumor in R1 models. Evens blue outlined the outer margin of tumor necrosis as a blue rim with viable tumor and normal liver much less stained (T1,T2,T3). At all time points, a perfect match was found between the high radioactive ring on the autoradiogram (T1a,T2a,T3a) and the blue rim on Evens blue stained sections of the same tumor. H&E stained macroscopy (T1b,T2b,T3b) and corresponding microscopy (Ta,Tb) confirmed the liver (L) viable tumor (V) and massive necrosis (N). Following CA4P treatment, a few layers of viable tumor cells always existed in the periphery with the typical thickness less than 100 µm (Tb).