Table 1.
Regional distribution of 123I-Hypericin (123I-Hyp) in rats with reperfused liver infarction (RLI) and hepatic implanted rhabdomyosorcoma-1(R1). Necrosis-to-liver ratios derived from scintillation detector were corrected by the corresponding measurements from autoradiography. Data are expressed as mean of % injected Dose/g (%ID/g) ± SD.
| Organ/ ratio | % injected dose per gram (%ID/g) | ||
|---|---|---|---|
| 4 h | 24 h | 48 h | |
| VL | 1.76 ± 0.54 | 0.41 ± 0.18↓ | 0.16 ± 0.07↓ |
| NL* | 3.94 ± 1.60 | 5.38 ± 1.04 | 6.03 ± 2.09 |
| NT* | 4.27 ± 0.76 | 5.57 ± 0.76 | 5.68 ± 1.33 |
| NL/ VL ratio | 2.23 ± 0.44 | 14.16 ± 3.93↑ | 37.58 ± 2.40↑ |
| NT/ VL ratio | 2.55 ± 0.75 | 14.87 ± 5.33↑ | 36.45 ± 6.44↑ |
VL: Viable Liver; NL: Necrotic Liver; NT: Necrotic Tumor. *: tissue that was stained by Evens Blue. ↓: decrease significantly (p<0.01) as compared with the previous measured time point. ↑: increase significantly (p<0.001) as compared with the previous measured time point.