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. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: Dev Neurobiol. 2012 Apr;72(4):628–648. doi: 10.1002/dneu.20967

Figure 6. In culture, RGC axon growth cones respond to acute netrin treatment with increased forward growth.

Figure 6

A, B) Time-lapse sequence of sample RGC axon growth cones imaged in culture under control conditions (A) and following acute exposure to netrin-1 (B). Scale bar, 10 µm. C) The increase in forward advancement of the growth cone from time 0 to subsequent observation intervals is shown by the relative increase in length for each individual axon (time 0 equals 100%). Note that treatment with netrin significantly increased the forward advancement of RGC growth cones in culture 10 minutes after treatment, in a dose-dependent manner.